Ku wa 30, Yokohama Rubber Co., Ltd., yatangaje ko yateguye ubuhinga bwa kera bw'isi kugira ngo buvemwo neza isoprene iva mu binyabuzima (isoprene ni ibikoresho vya mbere vyo guhingura umunyu w'ivyuma), kandi ishirahamwe na ryo nyene ryavuze ko Ubu buhinga bushobora no gukoreshwa mu guhingura umukate w'ivyuma vy'umubiri n'ibindi binyabiziga vya disne .
Mu mwaka w’2013, Yokohama Rubber na Ryan ubushakashatsi n’ubuhinga bwa Ryan vyatanguye iyo nyigisho, hakoreshejwe ubuhinga bwo guhingura ibintu bushingiye kuri mudasobwa kugira ngo bamenye uburyo bushasha bwo gukora isoprene mu myaka ibiri .
Yokohama yavuze ko izo nzira zitatu zarushirije gukora ubu buhinga bushasha, bushingiye ku enzyme ikora cane yaremwe, ikaba yatumye utugingo ngengabuzima tugira "isoprene nziza cane", kikaba carakozwe mu mubiri. Ubushobozi bw'ikintu (kenshi isukari) bwo guhingura isoprene kugira ngo ikore isoprene ivuye mu ngingo, gutyo igatahura ingene umugera wa polyisperene .
Yokohama yongeyeko ko isoprene muri rusangi yiyumviriwe ko ikozwe mu buryo busanzwe na aside pentanoïque, ari yo sukari ikozwe n’isukari, biciye mu nzira y’inzira zitanu, ariko umuhora wayo mushasha w’ubuhinga bw’ubuhinga bwubatswe n’ubushakashatsi bwakozwe n’urufatiro ushobora kugabanya iyo nzira ku gice ca kabiri .
Iryo shirahamwe kandi ryavuze ko iyo enzyme ikora cane ifise ubushobozi butangaje bwo gutanga isoprene idashoboka n’inzitizi z’ibidukikije. Mu gushiramwo izo enzyme muri E{1}} coli, imigera irashobora gutanga isoprene. Ubu iterwa ahanini n’ugusaduka kw’ubushuhe bwa naphtha.